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Saturday, April 18, 2020 | History

1 edition of Bioassay of dapsone for possible carcinogenicity. found in the catalog.

Bioassay of dapsone for possible carcinogenicity.

Bioassay of dapsone for possible carcinogenicity.

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  • 38 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Program, Carcinogen Bioasay and Program Resources Branch in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Sulphones -- Toxicology.

  • Edition Notes

    SeriesDHEW publication ; no. (NIH) 77-820, Carcinogenesis technical report series ; no. 20, DHEW publication -- no. (NIH) 77-820.
    The Physical Object
    Paginationxi, 97 p. :
    Number of Pages97
    ID Numbers
    Open LibraryOL15217041M

    Rodent cancer bioassays have a long history of identifying carcinogenic potential of synthetic and natural chemicals, chemical mixtures, and a variety of commercial products including :// Abstract. Although various approaches to carcinogenesis testing have been proposed [e. g., Weisburger and Williams (1)] involving short-term in vitro tests and limited or short-term in vivo tests using a tumorigenic endpoint, chronic carcinogenesis bioassay in animals is still the method most commonly used to detect the potential carcinogenicity of chemicals to :// Several drugs and related compounds which are secondary and tertiary amines were tested for mutagenicity with the Ames Salmonella/mammalian-microsome mutagenicity test, as were the products of their the 17 compounds tested, 3 were mutagenic (lucanthone, quinacrine, and thiram).   Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Below is the uncorrected machine-read text


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Bioassay of dapsone for possible carcinogenicity. Download PDF EPUB FB2

Bioassay of dapsone for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: Marshall Steinberg; National Cancer Institute (U.S.).

Carcinogen Bioassay and Program Resources :// Get this from a library. Bioassay of dapsone for possible carcinogenicity. [Carcinogenesis Program (National Cancer Institute (U.S.)).

Carcinogen Bioassay and Program Resources Branch.;]   A bioassay of dapsone, 4,4'-sulfonyldianiline, for possible carcinogenicity was conducted by administering the test material in Eeed to Fischer rats and B6C3F1 :// Bibliography: p.

A bioassay of dapsone, 4,4'-sulfonyldianiline, for possible carcinogenicity was conducted by administering the test material in feed to Fischer rats and B6C3F1 mice.

Groups of 35 rats and 35 mice of each sex were administered dapsone at one of two doses, either or 1, ppm for rats and either or 1, ppm for :// Carcinogenicity of dapsone in mice and rats Carcinogenicity of dapsone in mice and rats Griciute, Laima; Tomatis, L.

Dapsone (4,4'-diamino-diphenyl sulfone) has been tested for possible carcinogenicity in long-term animal experiments. BDIV rats and C,BL mice received a % aqueous suspension of dapsone by intragastric :// Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V.

() Reproducibility of microbial mutagenicity assays  › Home › Chemical Effects in Biological Systems (CEBS).

BIOASSAY OF ANTHRANILIC ACID FOR POSSIBLE CARCINOGENICITY CAS NO. [National Cancer Institute] on *FREE* shipping on qualifying offers. US Department of Health National Cancer Institute Carcinogenesis Technical Report no. We have been screening commonly used pharmaceuticals for possible carcinogenic effects for over 30 years, identifying drug recipients in an historical database consisting of prescriptions issued at the Kaiser Permanente San Francisco medical center topersons during the years to (2–5).

The minority of the committee believes that the process for selecting doses to be used in a carcinogenicity bioassay should be modified. Specifically, the minority recommends that dose selection be done by a panel of experts on the basis of careful evaluation of appropriate subchronic studies conducted before the bioassay is ://   4,4'-Sulfonyldianiline (Dapsone): Target Organs and Levels of Evidence for TR Bioassay of Dapsone for Possible Carcinogenicity (CASRN ) Chemical (Study Title)   A bioassay of hexachlorophene for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer rats.

Groups of 24 rats of each sex were administered hexachlorophene at one Bioassay of dapsone for possible carcinogenicity. book three doses, eit 50, or ppm, for weeks. Higher doses of ppm, used in 8-week subchronic   Long-Term Carcinogenicity. 2-Year (Dosed-Feed) (C) Completed.

TR (NIH Number: ) (Peer Review Approval 07/25/A) Bioassay of Dapsone for Possible Carcinogenicity (CASRN ) Rats: F/N; Mice: B6C3F1; Carcinogenesis Results. Male Rats Positive ; Female Rats Negative ; Male Mice Negative ; Female Mice Negative Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties.

As a structural analog of p-aminobenzoic acid (), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA :// Conducted for the Carcinogen Bioassay and Program Resources Branch, National Cancer Institute, by Southern Research Institute, Birmingham, Ala.

NLM ID: [Book] Carcinogenesis Program (National Cancer Institute (U.S.)). Carcinogen Bioassay and Program Resources Branch. Bioassay of dimethoate for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: Carcinogenesis Program (National Cancer   Bioassay of Dapsone for Possible Carcinogenicity, US Dept of Health, Education, and Welfare publication National Cancer Institute Carcinogenesis Technical Reports Series, National Cancer Institute Carcinogenesis Technical Reports Series,   A bioassay of 3,3'-iminobispropanol dimethanesulfonate (ester) hydrochloride [IPD] for possible carcinogenicity was conducted by administering the test chemical intraperitoneally to Sprague-Dawley rats and B6C3F1 mice.

The IPD was injected three times per week to groups of 35 animals, using doses of 12, 24, or 48 mg/kg for the rats, and 20 or 40 mg/kg for the ://,3'-iminobispropanol-(ester)-(IPD. Male rats given five daily doses of 1 to mg/kg body weight of "C-aniline accumulated covalently bound radioactivity m red blood cells and liver m a linear dose-dependent manner (the amount of bound material accumulating m liver was slight) However, accumulation of radioactivity m the spleen was seen only at daily doses greater than 10 mg/kg   A bioassay for possible carcinogenicity of technical-grade hexa­ chloroethane was conducted using Osborne-Mendel rats and B6C3F1 mice.

Hexachloroethane in corn oil was administered by gavage, at either of The present bioassay used to assess whole-sediment toxicity on benthic diatoms was applied in a ring test in which six laboratories in Spain and Portugal participated (Araújo et al., d).

Data indicated that the whole-sediment assay on C. closterium was considered sufficiently successful for possible use as a standard toxicity test due to National Cancer Institute (U.S.). Carcinogen Bioassay and Program Resources Branch. Bioassay of dimethoate for possible carcinogenicity (OCoLC) Online version: Carcinogenesis Program (National Cancer Institute (U.S.)).

Carcinogen Bioassay and Program Resources Branch. Bioassay of dimethoate for possible :// Online book: Additional Physical Format: Print version: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Bioassay of diazinon for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File The Linked Data Service provides access to commonly found standards and vocabularies promulgated by the Library of Congress.

This includes data values and the controlled vocabularies that house them. Datasets available include LCSH, BIBFRAME, LC Name Authorities, LC Classification, MARC codes, PREMIS vocabularies, ISO language codes, and |a Bioassay of dichlorvos for possible carcinogenicity |h [electronic resource] / |c Carcinogen Bioassay and Program Resources Branch, Carcinogenesis Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.

The compounds 4,4′-sulfonyldianiline (dapsone) and 4,4′-thiodianiline (I) were tested for possible carcinogenicity in F rats and B 6 C 3 F 1 mice. Groups of 35 rats and 35 mice of each sex were given either dapsone or compound (I) in the feed.

Matched controls consisted of 15 untreated rats and 14 untreated mice of each :// Its carcinogenicity has been studied only with high doses but these produced high levels of induced tumours.

Although the available data is limited, the analogy to the structurally similar substances 4,4'-diaminodiphenylmethane and 4,4'-oxydianiline justifies the classification of 4,4'-thiodianiline in Section III A 2) of the MAK 6.

Bioassay of pyrazinamide for possible carcinogenicity. National Cancer Institute Carcinogenesis Technical Report Series No.

48, 7. Zerger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of chemicals. Environ Mutagen. ; 9 (Suppl 9): ://   Dapsone 1 July Dapsone (4,4'-Diaminodiphenyl sulfone; 4,4'-Sulfonyldianiline) Dapsone is a sulfone used in the treatment of leprosy, alone or in combination with other drugs, and also as a primary treatment for Dermatitis herpetiformis.

Dapsone has also been used to |a Bioassay of sulfisoxazole for possible carcinogenicity |h [electronic resource] / |c Carcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Bioassay of piperonyl butoxide for possible carcinogenicity Published: () Bioassays of DDT, TDE, and p, p'-DDE for possible carcinogenicity Published: () Bioassay of dixathion for possible carcinogenicity Published: ()   Australian Public Assessment Report for dapsone.

Proprietary Product Name: Aczone. Tomatis L. Carcinogenicity of dapsone of mice and rats. Int. J Cancer. (); National Toxicology Program.

Bioassay of dapsone for possible carcinogenicity. Natl Cancer Inst. Carcinog. Tech Rep Ser. Expectations for Transgenic Rodent Cancer Bioassay Models Article Literature Review in Toxicologic Pathology 29 Suppl(5) February with 7 Reads How we measure 'reads' Bioassay of trisodium ethylenediaminetetraacetate trihydrate for possible carcinogenicity Published: () Bioassay of parathion for possible carcinogenicity Published: () Bioassay of toxaphene for possible carcinogenicity Published: () Bioassay of p, p'-ethyl-DDD for possible carcinogenicity Published: () Toxicological profile for heptachlor and heptachlor epoxide Published: ()   Bioassay of Dapsone for Possible Carcinogenicity, DHEW Publication No.

(NIG) 77– (Bethesda, Maryland: National Cancer Institute, ), viii. Two scientists had already discovered the basic mechanism (inhibiting oxidation of pyruvate) behind dapsone's carcinogenicity: D. Wu and K. DuBois, “Studies on the Mechanism of the Toxic A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the :// RightAnswer Knowledge Solutions provides access to hundreds of data sources.

Our premier and proprietary sources include fully-researched documents from well-established experts in the chemical and HazMat fields. • Bioassay of Dapsone for Possible Carcinogenicity (CAS No. ) (Report Date: ) REPROTOX® Documents Dapsone is an 1. Author(s): Litton-Bionetics, inc.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of styrene for possible 1.

Author(s): Southern Research Institute (Birmingham, Ala.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of acronycine for possible ://. The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.

The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis ://1.

Author(s): Hazleton Laboratories America.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of clonitralid for NCI,Bioassay of P-Cresidine for Possible Carcinogenicity, National Cancer Institute Carcinogenesis Technical Report Series No.

Google Scholar Peto, R.,Carcinogenic effects of chronic-exposure to very low levels of toxic substances, Environmental Health Perspectives,